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As a pharmacist's apprentice in Paderborn, he was the first to isolate morphine from opium. He called the isolated alkaloid "morphium" after the Greek god of dreams, Morpheus. He published a comprehensive paper on its isolation, crystallization, crystal structure, and pharmacological properties, which he studied first in stray dogs and then in self-experiments. It was not only the first alkaloid to be extracted from opium, but the first ever alkaloid to be isolated from any plant. Thus he became the first person to isolate the active ingredient associated with a medicinal plant or herb.In 1809, Sertürner opened his first own pharmacy in Einbeck. In 1822, he bought the main pharmacy in Hamelin (Rathaus Apotheke), where he worked until his death in 1841.